Senescence and Senolytics: Aether Medicine’s Approach to Longevity
Aging is a complex biological process, but recent advancements in cellular medicine have identified cellular senescence as one of the major contributors to age-related decline. At Aether Medicine, we leverage the latest research and therapies, such as senolytics, to address senescence and promote healthy aging. By targeting senescent cells, we aim to extend healthspan and improve overall vitality.
What is Cellular Senescence?
Cellular senescence occurs when a cell stops dividing and enters a state of permanent growth arrest in response to damage or stress. While this process is initially protective—preventing damaged cells from proliferating and potentially becoming cancerous—it has detrimental effects when senescent cells accumulate over time.
Senescent cells, often called “zombie cells,” remain metabolically active but secrete harmful molecules collectively referred to as the senescence-associated secretory phenotype (SASP). The SASP includes inflammatory cytokines, growth factors, and proteases that can damage surrounding tissues, drive chronic inflammation, and impair normal cellular function.
How Does Cellular Senescence Contribute to Aging?
Accumulation of senescent cells is one of the hallmarks of aging, driving many age-related diseases and conditions, including:
Chronic inflammation (inflammaging)
Reduced tissue regeneration and repair
Osteoarthritis and joint degeneration
Cardiovascular disease
Neurodegeneration
Metabolic dysfunction and insulin resistance
Over time, the presence of senescent cells accelerates the aging process, creating a cascade of tissue and organ dysfunction.
What Are Senolytics?
Senolytics are a class of therapies designed to selectively eliminate senescent cells without harming healthy ones. By removing these “zombie cells,” senolytics reduce the harmful effects of the SASP, decrease inflammation, and improve tissue function.
Senolytics are a promising tool for promoting longevity, reducing age-related diseases, and enhancing overall health. Examples of senolytic agents include:
Dasatinib and Quercetin (D+Q): A combination of a chemotherapy drug and a natural flavonoid that targets senescent cells in multiple tissues.
Fisetin: A plant-derived flavonoid with senolytic properties, shown to reduce senescent cell burden and improve healthspan in preclinical studies.
Navitoclax: A drug targeting pathways that help senescent cells survive, particularly effective in some tissues.
Aether Medicine’s Approach to Cellular Senescence
At Aether Medicine, we incorporate cutting-edge science and personalized care to address cellular senescence as part of our comprehensive approach to longevity. Here’s how we tackle senescence to promote healthy aging:
1. Advanced Diagnostics
We start by assessing your cellular health through a combination of advanced diagnostics, including markers of inflammation, metabolic function, and oxidative stress. These insights allow us to identify senescence-related dysfunction and create targeted interventions.
2. Personalized Senolytic Therapies
Based on your individual needs, we may recommend senolytic therapies to reduce the burden of senescent cells. Our approach may include:
Supplementation with Senolytic Agents such as quercetin, fisetin, and other evidence-based compounds.
Lifestyle Modifications to naturally reduce senescence, such as fasting, caloric restriction, and exercise.
3. Inflammation Reduction
By addressing chronic inflammation through targeted therapies like ozone therapy, peptides, and anti-inflammatory supplements, we mitigate the harmful effects of the SASP.
4. Mitochondrial Support
Senescent cells often have dysfunctional mitochondria, contributing to oxidative stress. We utilize mitochondria-boosting therapies, such as IV nutrition and mitochondrial-targeted supplements, to support cellular energy and repair.
5. Regenerative Therapies
We offer regenerative treatments like PRP (Platelet-Rich Plasma) and stem cell therapy to enhance tissue repair and combat the effects of cellular aging.
The Benefits of Addressing Senescence
Eliminating senescent cells and reducing their harmful effects can lead to profound improvements in health and quality of life. By targeting senescence, you may experience:
Reduced chronic inflammation and associated symptoms
Enhanced tissue repair and regeneration
Improved joint health and reduced stiffness
Better metabolic health, including insulin sensitivity
Increased energy and vitality
Longevity at Aether Medicine
At Aether Medicine, we don’t just treat symptoms—we address the root causes of aging and disease. By focusing on cellular senescence, we provide cutting-edge solutions to help you live longer, healthier, and more vibrant lives.
Our expertise in cellular medicine, combined with a deep understanding of the hallmarks of aging, allows us to craft personalized plans to support your longevity goals. From advanced diagnostics to senolytic therapies and regenerative treatments, we’re here to guide you on your journey to optimal health.
Reclaim your vitality and redefine aging with Aether Medicine. Let’s work together to create a future where you thrive.